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Accessory proteins such as zonula occludens (ZO)-1, ZO-2, AF-6, 7H6, and cingulin function as essential molecular bridges connecting transmembrane tight junction proteins to the intracellular actin cytoskeleton, thereby playing a critical role in preserving the structural and functional integrity of tight junctions (148)

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doi: 10.3389/fphar.2014.00260 Received 09 July 2014 Accepted 08 November 2014 Published 27 November 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Salvatore Salomone, Catania University, Italy